Ontology highlight
ABSTRACT:
SUBMITTER: Lucarelli G
PROVIDER: S-EPMC4537021 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Lucarelli Giuseppe G Galleggiante Vanessa V Rutigliano Monica M Sanguedolce Francesca F Cagiano Simona S Bufo Pantaleo P Lastilla Gaetano G Maiorano Eugenio E Ribatti Domenico D Giglio Andrea A Serino Grazia G Vavallo Antonio A Bettocchi Carlo C Selvaggi Francesco Paolo FP Battaglia Michele M Ditonno Pasquale P
Oncotarget 20150501 15
The analysis of cancer metabolome has shown that proliferating tumor cells require a large quantities of different nutrients in order to support their high rate of proliferation. In this study we analyzed the metabolic profile of glycolysis and the pentose phosphate pathway (PPP) in human clear cell-renal cell carcinoma (ccRCC) and evaluate the role of these pathways in sustaining cell proliferation, maintenance of NADPH levels, and production of reactive oxygen species (ROS). Metabolomic analys ...[more]