Orchestrating redox signaling networks through regulatory cysteine switches.
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ABSTRACT:
SUBMITTER: Paulsen CE
PROVIDER: S-EPMC4537063 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Publications
Orchestrating redox signaling networks through regulatory cysteine switches.
Paulsen Candice E CE Carroll Kate S KS
ACS chemical biology 20100101 1
Hydrogen peroxide (H(2)O(2)) acts as a second messenger that can mediate intracellular signal transduction via chemoselective oxidation of cysteine residues in signaling proteins. This Review presents current mechanistic insights into signal-mediated H(2)O(2) production and highlights recent advances in methods to detect reactive oxygen species (ROS) and cysteine oxidation both in vitro and in cells. Selected examples from the recent literature are used to illustrate the diverse mechanisms by wh ...[more]
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