A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability.
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ABSTRACT:
SUBMITTER: Flourakis M
PROVIDER: S-EPMC4537776 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability.
Flourakis Matthieu M Kula-Eversole Elzbieta E Hutchison Alan L AL Han Tae Hee TH Aranda Kimberly K Moose Devon L DL White Kevin P KP Dinner Aaron R AR Lear Bridget C BC Ren Dejian D Diekman Casey O CO Raman Indira M IM Allada Ravi R
Cell 20150801 4
Circadian clocks regulate membrane excitability in master pacemaker neurons to control daily rhythms of sleep and wake. Here, we find that two distinctly timed electrical drives collaborate to impose rhythmicity on Drosophila clock neurons. In the morning, a voltage-independent sodium conductance via the NA/NALCN ion channel depolarizes these neurons. This current is driven by the rhythmic expression of NCA localization factor-1, linking the molecular clock to ion channel function. In the evenin ...[more]
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