Ontology highlight
ABSTRACT:
SUBMITTER: Mack SC
PROVIDER: S-EPMC4537825 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Mack Stephen C SC Agnihotri Sameer S Bertrand Kelsey C KC Wang Xin X Wang Xin X Shih David J DJ Witt Hendrik H Hill Nadia N Zayne Kory K Barszczyk Mark M Ramaswamy Vijay V Remke Marc M Thompson Yuan Y Ryzhova Marina M Massimi Luca L Grajkowska Wieslawa W Lach Boleslaw B Gupta Nalin N Weiss William A WA Guha Abhijit A Hawkins Cynthia C Croul Sidney S Rutka James T JT Pfister Stefan M SM Korshunov Andrey A Pekmezci Melike M Tihan Tarik T Philips Joanna J JJ Jabado Nada N Zadeh Gelareh G Taylor Michael D MD
Clinical cancer research : an official journal of the American Association for Cancer Research 20150508 16
<h4>Purpose</h4>Myxopapillary ependymoma (MPE) is a distinct histologic variant of ependymoma arising commonly in the spinal cord. Despite an overall favorable prognosis, distant metastases, subarachnoid dissemination, and late recurrences have been reported. Currently, the only effective treatment for MPE is gross-total resection. We characterized the genomic and transcriptional landscape of spinal ependymomas in an effort to delineate the genetic basis of this disease and identify new leads fo ...[more]