Inhibition of MiR-155 suppresses cell migration in nasopharyngeal carcinoma through targeting ZDHHC2.
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ABSTRACT:
SUBMITTER: Jiang YX
PROVIDER: S-EPMC4538107 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Inhibition of MiR-155 suppresses cell migration in nasopharyngeal carcinoma through targeting ZDHHC2.
Jiang Yuan-Xue YX Du Zi-Ming ZM Jiao Lin L Shao Qiong Q Fu Sha S Shao Jian-Yong JY Zhu Xiao-Feng XF Ernberg Ingemar I Li Yu-Hong YH
International journal of clinical and experimental medicine 20150615 6
Overexpression of miR-155 in nasopharygeal carcinoma (NPC) is partly driven by Epstein-Bar virus infection. However the role of miR-155 in NPC oncogenesis is unclear. This study showed that miR-155 inhibitor could inhibit the cell migration in NPC cell lines. ZDHHC2 was identified as a direct target of miR-155 and downregulation of ZDHHC2 prompted cell migration in NPC. Furthermore, reduced ZDHHC2 expression was associated significantly with metastasis and poor survival of NPC patients. Collecti ...[more]
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