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Association of Vitamin D receptor gene TaqI polymorphisms with tuberculosis susceptibility: a meta-analysis.

ABSTRACT: Vitamin D receptor (VDR) is a receptor of vitamin D3, which plays a pivotal role in regulating cell proliferation and differentiation, lymphocyte activation and cytokine production, and is associated with TB susceptibility. Growing studies explored the association of TaqI polymorphism of VDR with tuberculosis (TB) susceptibility. However, the results were inconsistent and conflicting. To assess the relationship between the VDR TaqI gene polymorphism and the risk of TB, a meta-analysis was performed. Databases including PubMed and EMbase were systematically searched for genetic association studies of TaqI polymorphism of VDR and tuberculosis until February 15, 2015. Data were extracted by two independent authors and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated to assess the strength of the association between VDR TaqI gene polymorphism and TB risk, meta-regression and subgroup analyses were performed to identify the source of heterogeneity. Thirty-eight studies with a total of 6881 cases and 7511 controls were reviewed in the present meta-analysis. A statistically significant correlations were observed between VDR TaqI gene polymorphism and TB risk in South and West Asians (t vs. T: OR=1.27, 95% CI=1.07-1.51, P=0.007; tt vs. TT: OR=1.59, 95% CI=1.11-2.26, P=0.011; tt vs. Tt + TT: OR=1.43, 95% CI=1.17-1.73, P=0.000; tt + Tt vs. TT: OR=1.32, 95% CI=1.05-1.67, P=0.019). Heterogeneity between studies was not pronounced, and meta-regression found no source contributed to heterogeneity. However, after stratified analysis with respect to genotyping methods and sample size, significant association was found in "small" studies (<500 participants) and studies with "PCR-RFLP" methods. Synthesis of the available studies suggests that t allele of the VDR TaqI polymorphism is significantly associated with an increased TB risk in South and West Asians.

SUBMITTER: Cao Y

PROVIDER: S-EPMC4538126 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Association of Vitamin D receptor gene TaqI polymorphisms with tuberculosis susceptibility: a meta-analysis.

Cao Yan Y Wang Xinjing X Cao Zhihong Z Cheng Xiaoxing X

International journal of clinical and experimental medicine 20150615 6

Vitamin D receptor (VDR) is a receptor of vitamin D3, which plays a pivotal role in regulating cell proliferation and differentiation, lymphocyte activation and cytokine production, and is associated with TB susceptibility. Growing studies explored the association of TaqI polymorphism of VDR with tuberculosis (TB) susceptibility. However, the results were inconsistent and conflicting. To assess the relationship between the VDR TaqI gene polymorphism and the risk of TB, a meta-analysis was perfor ...[more]

PMID: 26309718

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Project description:BackgroundThere has been increasing interest in the study of the association between Vitamin D receptor (VDR) gene polymorphisms and risk of chronic periodontitis. However, the results remain inconclusive. To better understand the roles of VDR polymorphisms (BsmI, TaqI, FokI, and ApaI) in chronic periodontitis susceptibility, we conducted this systematic review and meta-analysis.Materials and methodsThe PubMed, Google Scholar, and Web of Science database were systemically searched to determine all the eligible studies about VDR polymorphisms and risk of chronic periodontitis up to April 2017. Odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the associations between VDR polymorphisms and chronic periodontitis risk. All the statistical analyses were performed by Comprehensive Meta-Analysis. All P values were two-tailed with a significant level at 0.05.ResultsFinally, a total of 38 case-control studies in 19 publications were identified which met our inclusion criteria. There are ten studies with 866 chronic periodontitis cases and 786 controls for BsmI, 16 studies with 1570 chronic periodontitis cases and 1676 controls for TaqI, five studies with 374 chronic periodontitis cases and 382 controls for FokI, and seven studies with 632 chronic periodontitis cases and 604 controls for ApaI. Overall, no significant association was observed between VDR gene BsmI, TaqI, FokI, and ApaI polymorphisms and risk of chronic periodontitis in any genetic model. Subgroup analysis stratified by ethnicity suggested a significant association between BsmI polymorphism and chronic periodontitis risk in the Caucasian subgroup under allele model (A vs. G: OR = 1.747, 95% CI = 1.099-2.778, P = 0.018). Further, no significant associations were observed when stratified by Hardy-Weinberg equilibrium status for BsmI, TaqI, and ApaI.ConclusionOur results suggest that BsmI, TaqI, FokI, and ApaI polymorphisms in the VDR gene might not be associated with risk of chronic periodontitis in overall population.

Dataset Information

Association of Vitamin D receptor gene TaqI polymorphisms with tuberculosis susceptibility: a meta-analysis.

Publications

Association of Vitamin D receptor gene TaqI polymorphisms with tuberculosis susceptibility: a meta-analysis.

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