Ontology highlight
ABSTRACT:
SUBMITTER: Manni A
PROVIDER: S-EPMC4538406 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Manni Andrea A El-Bayoumy Karam K Skibinski Christine G CG Thompson Henry J HJ Santucci-Pereira Julia J Bidinotto Lucas Tadeu LT Russo Jose J
BioMed research international 20150803
The molecular and biological heterogeneity of human breast cancer emphasizes the importance of a multitargeted approach for effective chemoprevention. Targeting the estrogen receptor pathway alone with the antiestrogens, Tamoxifen and Raloxifene reduces the incidence of estrogen receptor positive tumors but is ineffective against the development of hormone independent cancers. Our preclinical data indicate that the administration of omega-3 fatty acids potentiates the antitumor effects of Tamoxi ...[more]