The AT-Hook motif as a versatile minor groove anchor for promoting DNA binding of transcription factor fragments.

ABSTRACT: We report the development of chimeric DNA binding peptides comprising a DNA binding fragment of natural transcription factors (the basic region of a bZIP protein or a monomeric zinc finger module) and an AT-Hook peptide motif. The resulting peptide conjugates display high DNA affinity and excellent sequence selectivity. Furthermore, the AT-Hook motif also favors the cell internalization of the conjugates.

SUBMITTER: Rodriguez J 

PROVIDER: S-EPMC4538796 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature