Controlling the origins of inflammation with a photoactive lipopeptide immunopotentiator.
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ABSTRACT:
SUBMITTER: Mancini RJ
PROVIDER: S-EPMC4539149 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Publications
Controlling the origins of inflammation with a photoactive lipopeptide immunopotentiator.
Mancini Rock J RJ Stutts Lalisa L Moore Troy T Esser-Kahn Aaron P AP
Angewandte Chemie (International ed. in English) 20150320 20
Inflammatory immune responses are mediated by signaling molecules that are both produced by and recognized across highly heterogeneous cell populations. As such, the study of inflammation using traditional immunostimulants is complicated by paracrine and autocrine signaling, which obscures the origin of a propagating response. To address this challenge, we developed a small-molecule probe that can photosensitize immune cells, thus allowing light-mediated inflammation. This probe was used to cont ...[more]
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