Ontology highlight
ABSTRACT:
SUBMITTER: Yang W
PROVIDER: S-EPMC4539221 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Yang Wenli W Liu Ying Y Slovik Katherine J KJ Wu Joseph C JC Duncan Stephen A SA Rader Daniel J DJ Morrisey Edward E EE
PloS one 20150817 8
Although significant advancement has been made in the induced pluripotent stem cell (iPSC) field, current methods for iPSC derivation are labor intensive and costly. These methods involve manual selection, expansion, and characterization of multiple clones for each reprogrammed cell sample and therefore significantly hampers the feasibility of studies where a large number of iPSCs need to be derived. To develop higher throughput iPSC reprogramming methods, we generated iPSCs as a pooled culture ...[more]