Changes in vaginal microbiota following antimicrobial and probiotic therapy.
Ontology highlight
ABSTRACT: Background
The composition of the vaginal microbiota is known to be important for health. When infections occur, antimicrobial therapy is often poorly efficacious.Objective and design
We used 16S rRNA gene sequencing to characterize changes in the bacterial microbiota following oral antimicrobial and probiotic interventions.Results
While the bacterial vaginal profiles of women with vulvovaginal candidiasis were dominated by lactobacilli as in healthy women, and unchanged by therapy, Gardnerella vaginalis, Prevotella, Atopobium, Sneathia, and Megasphaera dominated the vagina of women with bacterial vaginosis (BV), and treatment with tinidazole plus Lactobacillus reuteri RC-14+L. rhamnosus GR-1 resulted in an increased relative abundance of indigenous L. iners or L. crispatus.Conclusions
The ability to restore homeostasis provides a rationale for conjoint use of probiotics with antibiotic treatment of BV.
SUBMITTER: Macklaim JM
PROVIDER: S-EPMC4539393 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Changes in vaginal microbiota following antimicrobial and probiotic therapy.
Macklaim Jean M JM Clemente Jose C JC Knight Rob R Gloor Gregory B GB Reid Gregor G
Microbial ecology in health and disease 20150814
<h4>Background</h4>The composition of the vaginal microbiota is known to be important for health. When infections occur, antimicrobial therapy is often poorly efficacious.<h4>Objective and design</h4>We used 16S rRNA gene sequencing to characterize changes in the bacterial microbiota following oral antimicrobial and probiotic interventions.<h4>Results</h4>While the bacterial vaginal profiles of women with vulvovaginal candidiasis were dominated by lactobacilli as in healthy women, and unchanged ...[more]
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