Ontology highlight
ABSTRACT:
SUBMITTER: Mei S
PROVIDER: S-EPMC4540422 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Mei Shiyue S Xin Jiaxuan J Liu Yu Y Zhang Yuan Y Liang Xue X Su Xiaomin X Yan Hui H Huang Yugang Y Yang Rongcun R
PloS one 20150818 8
Myeloid-derived suppressor cells (MDSCs) constitute one of the major populations that potently suppress anti-tumor immune responses and favor tumor growth in tumor microenvironment. However, the mechanism(s) regulating the differentiation and suppressive function of tumor-associated MDSCs remain(s) unclear. Here, we identified a microRNA-200c (miR-200c), whose expression was dramatically induced by tumor-derived factors. Meanwhile, we also demonstrated that GM-CSF was a main inducer of miR-200c ...[more]