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First Human Case of Fungal Keratitis Caused by a Putatively Novel Species of Lophotrichus.

ABSTRACT: We report an aggressive fungal keratitis caused by a putatively novel species of Lophotrichus in a patient with traumatic injury to the cornea from a dog paw. The organism was isolated from the patient's necrotic cornea, which perforated despite coverage with hourly fortified broad-spectrum topical antibiotic therapy. This report represents the first case of human infection caused by this species.

SUBMITTER: Eghrari AO

PROVIDER: S-EPMC4540931 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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First Human Case of Fungal Keratitis Caused by a Putatively Novel Species of Lophotrichus.

Eghrari Allen O AO Gibas Connie C Watkins Tonya T Vahedi Sina S Lee Rick R Houle Elizabeth E Suarez Maria Jose MJ Eberhart Charles C Sutton Deanna A DA Wiederhold Nathan P NP Sikder Shameema S Zhang Sean X SX

Journal of clinical microbiology 20150624 9

We report an aggressive fungal keratitis caused by a putatively novel species of Lophotrichus in a patient with traumatic injury to the cornea from a dog paw. The organism was isolated from the patient's necrotic cornea, which perforated despite coverage with hourly fortified broad-spectrum topical antibiotic therapy. This report represents the first case of human infection caused by this species. ...[more]

PMID: 26109445

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First case of fungal keratitis caused by Pestalotiopsis clavispora.

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Fungal keratitis caused by Macrophomina phaseolina - A case report.

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First case of fungal keratitis due to <i>Aspergillus minisclerotigenes</i> in Iran.

Project description:Background and purposeHerein, we report the first case of fungal keratitis due to Aspergillus minisclerotigenes in a 68-year-old rural woman admitted to the Ophthalmology Center of Khatam-Al-Anbia Hospital in Mashhad, northeast of Iran.Case reportThe patient presented with severe pain, burning, foreign body sensation, and reduced vision in her right eye. She had long-term uncontrolled diabetes and was not able to close her eye due to an anatomical problem with the eyelid. The cornea smear sample was cultured, and the fungus was initially identified as Aspergillus flavus. The isolated strain was further identified by sequencing a part of the calmodulin gene as A. minisclerotigenes. The patient did not respond to any antifungal treatments (e.g., amphotericin B and voriconazole drops, and fluconazole 300 mg/day); therefore, she was eventually subjected to corneal transplantation surgery.ConclusionFungal keratitis can be caused by the less common species. The reliable identification of the causative agents can be accomplished by the implementation of molecular methods.

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A Rare Case of Fungal Keratitis Caused by Plectosphaerella cucumerina Diagnosed With Repeated Corneal Scrapings: A Case Report.

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<i>Phialophora chinensis</i> fungal keratitis: An initial case report and species identification.

Project description:PurposeTo report the initial case of microbial keratitis caused by Phialophora chinensis, a rare cause of fungal keratitis.ObservationsA 66-year-old gentleman with a complex right eye (OD) ocular history including herpes simplex virus infectious epithelial keratitis with subsequent neurotrophic keratopathy, and prior combined Candida albicans and parapsilosis fungal keratitis presented with pain OD in the absence of an antecedent trauma. The patient was found to have a filamentous fungal keratitis, which was subsequently cultured and identified as Phialophora chinensis by the laboratory. Despite topical and oral antifungal treatment based on sensitivities determined by the lab, the patient ultimately required intrastromal and subconjunctival antifungal injections, corneal crosslinking, and superficial keratectomy with amniotic membrane to clinically improve. The fungal keratitis recurred twice, with each occurrence rapidly progressing to corneal perforation. Months after the second penetrating keratoplasty, the patient's mental status declined due to multiorgan failure. An occult pulmonary malignancy was discovered during this hospital stay, and the patient was lost to follow-up after entering hospice.Conclusions and importanceWe report a unique case of fungal keratitis caused by Phialophora chinensis and the subsequent management, including both medical and surgical interventions. Despite a multimodal treatment regimen, this case demonstrates the recalcitrant and potentially recurrent nature of fungal keratitis caused by P. chinensis.

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