Ontology highlight
ABSTRACT:
SUBMITTER: Marasek P
PROVIDER: S-EPMC4541046 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Marášek Pavel P Dzijak Rastislav R Studenyak Irina I Fišerová Jindřiška J Uličná Lívia L Novák Petr P Hozák Pavel P
Journal of cell science 20150626 16
Paxillin (PXN) is a focal adhesion protein that has been implicated in signal transduction from the extracellular matrix. Recently, it has been shown to shuttle between the cytoplasm and the nucleus. When inside the nucleus, paxillin promotes cell proliferation. Here, we introduce paxillin as a transcriptional regulator of IGF2 and H19 genes. It does not affect the allelic expression of the two genes; rather, it regulates long-range chromosomal interactions between the IGF2 or H19 promoter and a ...[more]