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Clinical Features of Obstructive Sleep Apnea That Determine Its High Prevalence in Resistant Hypertension.


ABSTRACT:

Purpose

Resistant hypertension (HTN) occurs in 15-20% of treated hypertensive patients, and 70-80% of resistant hypertensive patients have obstructive sleep apnea (OSA). The characteristics of resistant HTN that predispose patients to OSA have not been reported. Therefore, we aimed to determine the clinical, laboratory, and polysomnographic features of resistant HTN that are significantly associated with OSA.

Materials and methods

Hypertensive patients (n=475) who underwent portable polysomnography were enrolled. The patients were categorized into controlled (n=410) and resistant HTN (n=65) groups. The risk factors for the occurrence of OSA in controlled and resistant hypertensive patients were compared, and independent risk factors that are associated with OSA were analyzed.

Results

Out of 475 patients, 359 (75.6%) were diagnosed with OSA. The prevalence of OSA in resistant HTN was 87.7%, which was significantly higher than that in controlled HTN (73.7%). Age, body mass index, neck circumference, waist circumference, and hip circumference were significantly higher in OSA. However, stepwise multivariate analyses revealed that resistant HTN was not an independent risk factor of OSA.

Conclusion

The higher prevalence and severity of OSA in resistant HTN may be due to the association of risk factors that are common to both conditions.

SUBMITTER: Min HJ 

PROVIDER: S-EPMC4541655 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Clinical Features of Obstructive Sleep Apnea That Determine Its High Prevalence in Resistant Hypertension.

Min Hyun Jin HJ   Cho Yang-Je YJ   Kim Chang-Hoon CH   Kim Da Hee DH   Kim Ha Yan HY   Choi Ji In JI   Lee Jeung-Gweon JG   Park Sungha S   Cho Hyung-Ju HJ  

Yonsei medical journal 20150901 5


<h4>Purpose</h4>Resistant hypertension (HTN) occurs in 15-20% of treated hypertensive patients, and 70-80% of resistant hypertensive patients have obstructive sleep apnea (OSA). The characteristics of resistant HTN that predispose patients to OSA have not been reported. Therefore, we aimed to determine the clinical, laboratory, and polysomnographic features of resistant HTN that are significantly associated with OSA.<h4>Materials and methods</h4>Hypertensive patients (n=475) who underwent portab  ...[more]

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