Ontology highlight
ABSTRACT:
SUBMITTER: Spira A
PROVIDER: S-EPMC454179 | biostudies-literature | 2004 Jul
REPOSITORIES: biostudies-literature
Spira Avrum A Beane Jennifer J Shah Vishal V Liu Gang G Schembri Frank F Yang Xuemei X Palma John J Brody Jerome S JS
Proceedings of the National Academy of Sciences of the United States of America 20040621 27
Cigarette smoke is the major cause of lung cancer, the leading cause of cancer death, and of chronic obstructive pulmonary disease, the fourth leading cause of death in the United States. Using high-density gene expression arrays, we describe genes that are normally expressed in a subset of human airway epithelial cells obtained at bronchoscopy (the airway transcriptome), define how cigarette smoking alters the transcriptome, and detail the effects of variables, such as cumulative exposure, age, ...[more]