Ontology highlight
ABSTRACT:
SUBMITTER: Yu R
PROVIDER: S-EPMC4542547 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Yu Rilei R Seymour Victoria A L VA Berecki Géza G Jia Xinying X Akcan Muharrem M Adams David J DJ Kaas Quentin Q Craik David J DJ
Scientific reports 20150820
Cyclic α-conotoxin Vc1.1 (cVc1.1) is an orally active peptide with analgesic activity in rat models of neuropathic pain. It has two disulfide bonds, which can have three different connectivities, one of which is the native and active form. In this study we used computational modeling and nuclear magnetic resonance to design a disulfide-deleted mutant of cVc1.1, [C2H,C8F]cVc1.1, which has a larger hydrophobic core than cVc1.1 and, potentially, additional surface salt bridge interactions. The new ...[more]