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Use of influenza antiviral medications among outpatients at high risk for influenza-associated complications during the 2013-2014 influenza season.

ABSTRACT: During the 2013-2014 influenza season, we analyzed data from 6004 outpatients aged ?6 months with acute respiratory illness (ARI). Among the 2786 ARI patients at higher risk for influenza complications, 835 (30%) presented to care ?2 days from symptom onset; among those, 126 (15%) were prescribed an antiviral medication.

SUBMITTER: Havers F

PROVIDER: S-EPMC4542604 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Use of influenza antiviral medications among outpatients at high risk for influenza-associated complications during the 2013-2014 influenza season.

Havers Fiona F Flannery Brendan B Clippard Jessie R JR Gaglani Manjusha M Zimmerman Richard K RK Jackson Lisa A LA Petrie Joshua G JG McLean Huong Q HQ Nowalk Mary Patricia MP Jackson Michael L ML Monto Arnold S AS Belongia Edward A EA Eng Heather F HF Lamerato Lois L Campbell Angela P AP Fry Alicia M AM

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20150225 11

During the 2013-2014 influenza season, we analyzed data from 6004 outpatients aged ≥6 months with acute respiratory illness (ARI). Among the 2786 ARI patients at higher risk for influenza complications, 835 (30%) presented to care ≤2 days from symptom onset; among those, 126 (15%) were prescribed an antiviral medication. ...[more]

PMID: 25722198

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Project description:BackgroundThe Global Influenza Hospital Surveillance Network was established in 2012 to obtain valid epidemiologic data on hospital admissions with influenza-like illness. Here we describe the epidemiology of admissions with influenza within the Northern Hemisphere sites during the 2013/2014 influenza season, identify risk factors for severe outcomes and complications, and assess the impact of different influenza viruses on clinically relevant outcomes in at-risk populations.MethodsEligible consecutive admissions were screened for inclusion at 19 hospitals in Russia, Turkey, China, and Spain using a prospective, active surveillance approach. Patients that fulfilled a common case definition were enrolled and epidemiological data were collected. Risk factors for hospitalization with laboratory-confirmed influenza were identified by multivariable logistic regression.Findings5303 of 9507 consecutive admissions were included in the analysis. Of these, 1086 were influenza positive (534 A(H3N2), 362 A(H1N1), 130 B/Yamagata lineage, 3 B/Victoria lineage, 40 untyped A, and 18 untyped B). The risk of hospitalization with influenza (adjusted odds ratio [95% confidence interval]) was elevated for patients with cardiovascular disease (1.63 [1.33-2.02]), asthma (2.25 [1.67-3.03]), immunosuppression (2.25 [1.23-4.11]), renal disease (2.11 [1.48-3.01]), liver disease (1.94 [1.18-3.19], autoimmune disease (2.97 [1.58-5.59]), and pregnancy (3.84 [2.48-5.94]). Patients without comorbidities accounted for 60% of admissions with influenza. The need for intensive care or in-hospital death was not significantly different between patients with or without influenza. Influenza vaccination was associated with a lower risk of confirmed influenza (adjusted odds ratio = 0.61 [0.48-0.77]).ConclusionsInfluenza infection was detected among hospital admissions with and without known risk factors. Pregnancy and underlying comorbidity increased the risk of detecting influenza virus in patients hospitalized with influenza-like illness. Our results support influenza vaccination as a measure for reducing the risk of influenza-associated hospital admission.

Dataset Information

Use of influenza antiviral medications among outpatients at high risk for influenza-associated complications during the 2013-2014 influenza season.

Publications

Use of influenza antiviral medications among outpatients at high risk for influenza-associated complications during the 2013-2014 influenza season.

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