Efficient heterocyclisation by (di)terpene synthases.
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ABSTRACT:
SUBMITTER: Mafu S
PROVIDER: S-EPMC4543578 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Publications
Efficient heterocyclisation by (di)terpene synthases.
Mafu S S Potter K C KC Hillwig M L ML Schulte S S Criswell J J Peters R J RJ
Chemical communications (Cambridge, England) 20150901 70
While cyclic ether forming terpene synthases are known, the basis for such heterocyclisation is unclear. Here it is reported that numerous (di)terpene synthases, particularly including the ancestral ent-kaurene synthase, efficiently produce isomers of manoyl oxide from the stereochemically appropriate substrate. Accordingly, such heterocyclisation is easily accomplished by terpene synthases. Indeed, the use of single residue changes to induce production of the appropriate substrate in the upstre ...[more]
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