Ontology highlight
ABSTRACT:
SUBMITTER: Lucato CM
PROVIDER: S-EPMC4543645 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Lucato Christina M CM Halls Michelle L ML Ooms Lisa M LM Liu Heng-Jia HJ Mitchell Christina A CA Whisstock James C JC Ellisdon Andrew M AM
The Journal of biological chemistry 20150624 34
The P-Rex (phosphatidylinositol (3,4,5)-trisphosphate (PIP3)-dependent Rac exchanger) family (P-Rex1 and P-Rex2) of the Rho guanine nucleotide exchange factors (Rho GEFs) activate Rac GTPases to regulate cell migration, invasion, and metastasis in several human cancers. The family is unique among Rho GEFs, as their activity is regulated by the synergistic binding of PIP3 and Gβγ at the plasma membrane. However, the molecular mechanism of this family of multi-domain proteins remains unclear. We r ...[more]