Ontology highlight
ABSTRACT:
SUBMITTER: Hansen SD
PROVIDER: S-EPMC4543927 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Hansen Scott D SD Mullins R Dyche RD
eLife 20150821
Enabled/Vasodilator (Ena/VASP) proteins promote actin filament assembly at multiple locations, including: leading edge membranes, focal adhesions, and the surface of intracellular pathogens. One important Ena/VASP regulator is the mig-10/Lamellipodin/RIAM family of adaptors that promote lamellipod formation in fibroblasts and drive neurite outgrowth and axon guidance in neurons. To better understand how MRL proteins promote actin network formation we studied the interactions between Lamellipodin ...[more]