Ontology highlight
ABSTRACT:
SUBMITTER: Goodwin M
PROVIDER: S-EPMC4545389 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Goodwin Marianne M Mohan Apoorva A Batra Ranjan R Lee Kuang-Yung KY Charizanis Konstantinos K Fernández Gómez Francisco José FJ Eddarkaoui Sabiha S Sergeant Nicolas N Buée Luc L Kimura Takashi T Clark H Brent HB Dalton Joline J Takamura Kenji K Weyn-Vanhentenryck Sebastien M SM Zhang Chaolin C Reid Tammy T Ranum Laura P W LP Day John W JW Swanson Maurice S MS
Cell reports 20150806 7
For some neurological disorders, disease is primarily RNA mediated due to expression of non-coding microsatellite expansion RNAs (RNA(exp)). Toxicity is thought to result from enhanced binding of proteins to these expansions and depletion from their normal cellular targets. However, experimental evidence for this sequestration model is lacking. Here, we use HITS-CLIP and pre-mRNA processing analysis of human control versus myotonic dystrophy (DM) brains to provide compelling evidence for this RN ...[more]