Ontology highlight
ABSTRACT:
SUBMITTER: Thompson ML
PROVIDER: S-EPMC4545688 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Thompson Michelle L ML Jimenez-Andrade Juan M JM Chartier Stephane S Tsai James J Burton Elizabeth A EA Habets Gaston G Lin Paul S PS West Brian L BL Mantyh Patrick W PW
Pain 20150901 9
Tumor cells frequently metastasize to bone where they can generate cancer-induced bone pain (CIBP) that can be difficult to fully control using available therapies. Here, we explored whether PLX3397, a high-affinity small molecular antagonist that binds to and inhibits phosphorylation of colony-stimulating factor-1 receptor, the tyrosine-protein kinase c-Kit, and the FMS-like tyrosine kinase 3, can reduce CIBP. These 3 targets all regulate the proliferation and function of a subset of the myeloi ...[more]