Ontology highlight
ABSTRACT:
SUBMITTER: Zheng Y
PROVIDER: S-EPMC4546194 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Zheng Yaning Y Tang Lin L Huang Wenhan W Yan Ruyu R Ren Feifeng F Luo Lei L Zhang Ling L
PloS one 20150820 8
The angiotensin converting enzyme 2-angiotensin-(1-7)-Mas axis (ACE2-Ang-(1-7)-Mas axis) is reported to participate in lipid metabolism in kidney, but its precise effects and underlying mechanisms remain unknown. We hypothesized that Ang-(1-7) reduces lipid accumulation and improves renal injury through the low density lipoprotein receptor-sterol regulatory element binding proteins 2-SREBP cleavage activating protein (LDLr-SREBP2-SCAP) system by suppressing inflammation in high fat diet (HFD)-fe ...[more]