Ontology highlight
ABSTRACT:
SUBMITTER: Onorati MC
PROVIDER: S-EPMC4546373 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Onorati Maria Cristina MC Arancio Walter W Cavalieri Vincenzo V Ingrassia Antonia M R AM Pavesi Giulio G Corona Davide F V DF
PLoS genetics 20150820 8
In order to study the role played by cellular RNA pools produced by homologous genomic loci in defining the transcriptional state of a silenced gene, we tested the effect of non-functional alleles of the white gene in the presence of a functional copy of white, silenced by heterochromatin. We found that non-functional alleles of white, unable to produce a coding transcript, could reactivate in trans the expression of a wild type copy of the same gene silenced by heterochromatin. This new epigene ...[more]