Ontology highlight
ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC4546474 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Wang Huanan H Zhang Lingling L Yang Xu X Jin Yipeng Y Pei Shimin S Zhang Di D Zhang Hong H Zhou Bin B Zhang Yingjie Y Lin Degui D
Oncotarget 20150601 16
Colon cancer is the third most common cancer in humans which has a high mortality rate, and 5-Fluorouracil (5-FU) is one of the most widely used drugs in colon cancer therapy. However, acquired chemoresistance is becoming the major challenges for patients, and the molecular mechanism underlying the development of 5-FU resistance is still poorly understood. In this study, a newly designed therapy in combination with 5-FU and NVP-BEZ235 in colon cancer cells (HCT-116 and RKO) was established, to i ...[more]