Ontology highlight
ABSTRACT:
SUBMITTER: Ndjomou J
PROVIDER: S-EPMC4546510 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
ACS chemical biology 20150522 8
This study examines the specificity and mechanism of action of a recently reported hepatitis C virus (HCV) nonstructural protein 3 (NS3) helicase-protease inhibitor (HPI), and the interaction of HPI with the NS3 protease inhibitors telaprevir, boceprevir, danoprevir, and grazoprevir. HPI most effectively reduced cellular levels of subgenomic genotype 4a replicons, followed by genotypes 3a and 1b replicons. HPI had no effect on HCV genotype 2a or dengue virus replicon levels. Resistance evolved m ...[more]