Ontology highlight
ABSTRACT:
SUBMITTER: Castellano LM
PROVIDER: S-EPMC4546571 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Castellano Laura M LM Bart Stephen M SM Holmes Veronica M VM Weissman Drew D Shorter James J
Chemistry & biology 20150806 8
Naturally occurring proteolytic fragments of prostatic acid phosphatase (PAP248-286 and PAP85-120) and semenogelins (SEM1 and SEM2) form amyloid fibrils in seminal fluid, which capture HIV virions and promote infection. For example, PAP248-286 fibrils, termed SEVI (semen-derived enhancer of viral infection), can potentiate HIV infection by several orders of magnitude. Here, we design three disruptive technologies to rapidly antagonize seminal amyloid by repurposing Hsp104, an amyloid-remodeling ...[more]