Commentary: IL-4 and IL-13 receptors and signaling.
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ABSTRACT:
SUBMITTER: McCormick SM
PROVIDER: S-EPMC4546937 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
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Commentary: IL-4 and IL-13 receptors and signaling.
McCormick Sarah M SM Heller Nicola M NM
Cytokine 20150714 1
Interleukin (IL)-4 and IL-13 were discovered approximately 30years ago and were immediately linked to allergy and atopic diseases. Since then, new roles for IL-4 and IL-13 and their receptors in normal gestation, fetal development and neurological function and in the pathogenesis of cancer and fibrosis have been appreciated. Studying IL-4/-13 and their receptors has revealed important clues about cytokine biology and led to the development of numerous experimental therapeutics. Here we aim to hi ...[more]
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