Parity and Cardiovascular Disease Mortality: a Dose-Response Meta-Analysis of Cohort Studies.

ABSTRACT: Parity has been shown to inversely associate with cardiovascular disease (CVD) mortality, but the evidence of epidemiological studies is still controversial. Therefore, we quantitatively assessed the relationship between parity and CVD mortality by summarizing the evidence from prospective studies. We searched MEDLINE (PubMed), EMBASE and ISI Web of Science databases for relevant prospective studies of parity and CVD mortality through the end of March 2015. Fixed- or random-effects models were used to estimate summary relative risks (RRs) and 95% confidence intervals (CIs). Heterogeneity among studies was assessed using the I(2) statistics. All statistical tests were two-sided. Ten prospective studies were included with a total of 994,810 participants and 16,601 CVD events. A borderline significant inverse association was observed while comparing parity with nulliparous, with summarized RR?=?0.79 (95% CI: 0.60-1.06; I(2)?=?90.9%, P?

SUBMITTER: Lv H 

PROVIDER: S-EPMC4547137 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature