Anionic Lipids Modulate the Activity of the Aquaglyceroporin GlpF.
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ABSTRACT:
SUBMITTER: Klein N
PROVIDER: S-EPMC4547167 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
Anionic Lipids Modulate the Activity of the Aquaglyceroporin GlpF.
Klein Noreen N Hellmann Nadja N Schneider Dirk D
Biophysical journal 20150801 4
The structure and composition of a biological membrane can severely influence the activity of membrane-embedded proteins. Here, we show that the E. coli aquaglyceroporin GlpF has only little activity in lipid bilayers formed from native E. coli lipids. Thus, at first glance, GlpF appears to not be optimized for its natural membrane environment. In fact, we found that GlpF activity was severely affected by negatively charged lipids regardless of the exact chemical nature of the lipid headgroup, w ...[more]
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