Ontology highlight
ABSTRACT:
SUBMITTER: Ottosson NE
PROVIDER: S-EPMC4547393 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Ottosson Nina E NE Wu Xiongyu X Nolting Andreas A Karlsson Urban U Lund Per-Eric PE Ruda Katinka K Svensson Stefan S Konradsson Peter P Elinder Fredrik F
Scientific reports 20150824
Voltage-gated ion channels generate cellular excitability, cause diseases when mutated, and act as drug targets in hyperexcitability diseases, such as epilepsy, cardiac arrhythmia and pain. Unfortunately, many patients do not satisfactorily respond to the present-day drugs. We found that the naturally occurring resin acid dehydroabietic acid (DHAA) is a potent opener of a voltage-gated K channel and thereby a potential suppressor of cellular excitability. DHAA acts via a non-traditional mechanis ...[more]