Ontology highlight
ABSTRACT:
SUBMITTER: Wilson JN
PROVIDER: S-EPMC4548262 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Wilson James N JN Liu Wenjun W Brown Adrienne S AS Landgraf Ralf R
Organic & biomolecular chemistry 20150501 17
We report the photophysical properties, binding-induced turn-on emission, and fluorescence imaging of the cellular uptake and distribution of lapatinib, an EGFR/ERBB inhibitor. Lapatinib, a type II, i.e. inactive state, inhibitor that targets the ATP binding pocket of the EGFR family of receptor tyrosine kinases. DFT calculations predict that the 6-furanylquinazoline core of lapatinib should exhibit an excited state with charge transfer character and an S0 to S1 transition energy of 3.4 eV. Abso ...[more]