Ontology highlight
ABSTRACT:
SUBMITTER: Ollier M
PROVIDER: S-EPMC4548324 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Ollier Marie M Radosevic-Robin Nina N Kwiatkowski Fabrice F Ponelle Flora F Viala Sandrine S Privat Maud M Uhrhammer Nancy N Bernard-Gallon Dominique D Penault-Llorca Frédérique F Bignon Yves-Jean YJ Bidet Yannick Y
American journal of cancer research 20150615 7
Among breast cancers, 10 to 15% of cases would be due to hereditary risk. In these familial cases, mutations in BRCA1 and BRCA2 are found in only 15% to 20%, meaning that new susceptibility genes remain to be found. Triple-negative breast cancers represent 15% of all breast cancers, and are generally aggressive tumours without targeted therapies available. Our hypothesis is that some patients with triple negative breast cancer could share a genetic susceptibility different from other types of br ...[more]