Ontology highlight
ABSTRACT:
SUBMITTER: Zurek OW
PROVIDER: S-EPMC4548456 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Zurek Oliwia W OW Pallister Kyler B KB Voyich Jovanka M JM
The Journal of infectious diseases 20150226 6
While Staphylococcus aureus accelerates human neutrophil cell death, the underlying host- and pathogen-derived mechanisms remain incompletely defined. Previous studies demonstrated that the S. aureus SaeR/S sensory system is essential for pathogen survival following neutrophil phagocytosis. Herein, we demonstrate that the SaeR/S system promoted accelerated cell death, suppressed phosphorylation of nuclear factor-κB, and reduced interleukin-8 (IL-8) production in human neutrophils. Treatment of n ...[more]