Ontology highlight
ABSTRACT:
SUBMITTER: Schwendeman A
PROVIDER: S-EPMC4548777 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Schwendeman Anna A Sviridov Denis O DO Yuan Wenmin W Guo Yanhong Y Morin Emily E EE Yuan Yue Y Stonik John J Freeman Lita L Ossoli Alice A Thacker Seth S Killion Salena S Pryor Milton M Chen Y Eugene YE Turner Scott S Remaley Alan T AT
Journal of lipid research 20150627 9
The goal of this study was to understand how the reconstituted HDL (rHDL) phospholipid (PL) composition affects its cholesterol efflux and anti-inflammatory properties. An ApoA-I mimetic peptide, 5A, was combined with either SM or POPC. Both lipid formulations exhibited similar in vitro cholesterol efflux by ABCA1, but 5A-SM exhibited higher ABCG1- and SR-BI-mediated efflux relative to 5A-POPC (P < 0.05). Injection of both rHDLs in rats resulted in mobilization of plasma cholesterol, although th ...[more]