Blunted suppression of acyl-ghrelin in response to fructose ingestion in obese adolescents: the role of insulin resistance.
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ABSTRACT:
SUBMITTER: Van Name M
PROVIDER: S-EPMC4548801 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Publications
Blunted suppression of acyl-ghrelin in response to fructose ingestion in obese adolescents: the role of insulin resistance.
Van Name Michelle M Giannini Cosimo C Santoro Nicola N Jastreboff Ania M AM Kubat Jessica J Li Fangyong F Kursawe Romy R Savoye Mary M Duran Elvira E Dziura James J Sinha Rajita R Sherwin Robert S RS Cline Gary G Caprio Sonia S
Obesity (Silver Spring, Md.) 20150203 3
<h4>Objective</h4>Fructose consumption has risen alongside obesity and diabetes. Gut hormones involved in hunger and satiety (ghrelin and PYY) may respond differently to fructose compared with glucose ingestion. This study evaluated the effects of glucose and fructose ingestion on ghrelin and PYY in lean and obese adolescents with differing insulin sensitivity.<h4>Methods</h4>Adolescents were divided into lean (n = 14), obese insulin sensitive (n = 12) (OIS), and obese insulin resistant (n = 15) ...[more]
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