Systemic inflammatory response and serum lipopolysaccharide levels predict multiple organ failure and death in alcoholic hepatitis.
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ABSTRACT:
SUBMITTER: Michelena J
PROVIDER: S-EPMC4549175 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
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Systemic inflammatory response and serum lipopolysaccharide levels predict multiple organ failure and death in alcoholic hepatitis.
Michelena Javier J Altamirano José J Abraldes Juan G JG Affò Silvia S Morales-Ibanez Oriol O Sancho-Bru Pau P Dominguez Marlene M García-Pagán Juan Carlos JC Fernández Javier J Arroyo Vicente V Ginès Pere P Louvet Alexandre A Mathurin Philippe P Mehal Wajahat Z WZ Caballería Juan J Bataller Ramón R
Hepatology (Baltimore, Md.) 20150413 3
<h4>Unlabelled</h4>Alcoholic hepatitis (AH) frequently progresses to multiple organ failure (MOF) and death. However, the driving factors are largely unknown. At admission, patients with AH often show criteria of systemic inflammatory response syndrome (SIRS) even in the absence of an infection. We hypothesize that the presence of SIRS may predispose to MOF and death. To test this hypothesis, we studied a cohort including 162 patients with biopsy-proven AH. The presence of SIRS and infections wa ...[more]
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