Axl receptor tyrosine kinase expression in breast cancer.

ABSTRACT:

Aims

Triple-negative breast cancer comprises a clinically aggressive group of invasive carcinomas. We examined a published gene expression screen of a panel of breast cancer cell lines to identify a potential triple-negative breast cancer-specific gene signature, and attempted to verify our findings by performing immunohistochemical analysis on tissue microarrays containing a large cohort of invasive breast carcinomas.

Methods

The microarray dataset for a panel of human breast cancer cell lines was interrogated for triple-negative breast cancer-specific genes. Membranous immunohistochemical expression of the protein product of the AXL gene was assessed semiquantitatively in 569 invasive breast carcinomas grouped according to molecular subgroup by immunohistochemistry.

Res

SUBMITTER: D'Alfonso TM 

PROVIDER: S-EPMC4549806 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature