Ontology highlight
ABSTRACT:
SUBMITTER: Shahane SA
PROVIDER: S-EPMC4550094 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Shahane Sampada A SA Huang Ruili R Gerhold David D Baxa Ulrich U Austin Christopher P CP Xia Menghang M
Journal of biomolecular screening 20130903 1
Drug-induced phospholipidosis is characterized by the accumulation of intracellular phospholipids in cells exposed to cationic amphiphilic drugs. The appearance of unicentric or multicentric multilamellar bodies viewed under an electron microscope (EM) is the morphological hallmark of phospholipidosis. Although the EM method is the gold standard for detecting cellular phospholipidosis, this method has its drawbacks, including low throughput, high cost, and unsuitability for screening a large che ...[more]