A Novel Isoquinoline Derivative Anticancer Agent and Its Targeted Delivery to Tumor Cells Using Transferrin-Conjugated Liposomes.
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ABSTRACT:
SUBMITTER: Yang X
PROVIDER: S-EPMC4550422 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
A Novel Isoquinoline Derivative Anticancer Agent and Its Targeted Delivery to Tumor Cells Using Transferrin-Conjugated Liposomes.
Yang Xuewei X Yang Shuang S Chai Hongyu H Yang Zhaogang Z Lee Robert J RJ Liao Weiwei W Teng Lesheng L
PloS one 20150826 8
We have screened 11 isoquinoline derivatives and α-methylene-γ-butyrolactones using the 3-(4,5-dimethylthi-azol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cytotoxicity assay in HeLa and HEK-293T cells. Compound 2 was identified as potential anticancer agent. To further improve its therapeutic potential, this agent was incorporated into transferrin (Tf)-conjugated liposomes (LPs) for targeted delivery to tumor cells. We have demonstrated Tf-LP-Compound 2 have superior antitumor activity compared ...[more]
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