Oncolytic adenovirus research evolution: from cell-cycle checkpoints to immune checkpoints.
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ABSTRACT:
SUBMITTER: Jiang H
PROVIDER: S-EPMC4550502 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
Oncolytic adenovirus research evolution: from cell-cycle checkpoints to immune checkpoints.
Jiang Hong H Gomez-Manzano Candelaria C Rivera-Molina Yisel Y Lang Frederick F FF Conrad Charles A CA Fueyo Juan J
Current opinion in virology 20150413
Oncolytic adenoviruses are modified to exploit the aberrant expression of proteins in cancer cells to obtain cancer-selective replication. Moreover, the natural tropism of oncolytic adenoviruses can be redirected to tumor cells. Clinical trials revealed that oncolytic viruses showed poor replication in the tumor that is due in part to the immune response against the virus. More recent data demonstrated that tumor infection might subvert the tumor immune system and lead to an anti-tumor immune re ...[more]
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