Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration.
Ontology highlight
ABSTRACT:
SUBMITTER: Mahmoud AI
PROVIDER: S-EPMC4550513 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration.
Mahmoud Ahmed I AI O'Meara Caitlin C CC Gemberling Matthew M Zhao Long L Bryant Donald M DM Zheng Ruimao R Gannon Joseph B JB Cai Lei L Choi Wen-Yee WY Egnaczyk Gregory F GF Burns Caroline E CE Burns C Geoffrey CG MacRae Calum A CA Poss Kenneth D KD Lee Richard T RT
Developmental cell 20150806 4
Some organisms, such as adult zebrafish and newborn mice, have the capacity to regenerate heart tissue following injury. Unraveling the mechanisms of heart regeneration is fundamental to understanding why regeneration fails in adult humans. Numerous studies have revealed that nerves are crucial for organ regeneration, thus we aimed to determine whether nerves guide heart regeneration. Here, we show using transgenic zebrafish that inhibition of cardiac innervation leads to reduction of myocyte pr ...[more]
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