Ontology highlight
ABSTRACT:
SUBMITTER: Bakan A
PROVIDER: S-EPMC4551054 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Bakan Ahmet A Kapralov Alexandr A AA Bayir Hulya H Hu Feizhou F Kagan Valerian E VE Bahar Ivet I
Molecular pharmacology 20150615 3
Cytochrome c (cyt c) release from mitochondria is accepted to be the point of no return for eliciting a cascade of interactions that lead to apoptosis. A strategy for containing sustained apoptosis is to reduce the mitochondrial permeability pore opening. Pore opening is enhanced by peroxidase activity of cyt c gained upon its complexation with cardiolipin in the presence of reactive oxygen species. Blocking access to the heme group has been proposed as an effective intervention method for reduc ...[more]