Ontology highlight
ABSTRACT:
SUBMITTER: Olsson E
PROVIDER: S-EPMC4551342 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Olsson Eleonor E Winter Christof C George Anthony A Chen Yilun Y Howlin Jillian J Tang Man-Hung Eric MH Dahlgren Malin M Schulz Ralph R Grabau Dorthe D van Westen Danielle D Fernö Mårten M Ingvar Christian C Rose Carsten C Bendahl Pär-Ola PO Rydén Lisa L Borg Åke Å Gruvberger-Saal Sofia K SK Jernström Helena H Saal Lao H LH
EMBO molecular medicine 20150801 8
Metastatic breast cancer is usually diagnosed after becoming symptomatic, at which point it is rarely curable. Cell-free circulating tumor DNA (ctDNA) contains tumor-specific chromosomal rearrangements that may be interrogated in blood plasma. We evaluated serial monitoring of ctDNA for earlier detection of metastasis in a retrospective study of 20 patients diagnosed with primary breast cancer and long follow-up. Using an approach combining low-coverage whole-genome sequencing of primary tumors ...[more]