Ontology highlight
ABSTRACT:
SUBMITTER: Giordano M
PROVIDER: S-EPMC4551351 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Giordano Marilyn M Henin Coralie C Maurizio Julien J Imbratta Claire C Bourdely Pierre P Buferne Michel M Baitsch Lukas L Vanhille Laurent L Sieweke Michael H MH Speiser Daniel E DE Auphan-Anezin Nathalie N Schmitt-Verhulst Anne-Marie AM Verdeil Grégory G
The EMBO journal 20150702 15
T cells infiltrating neoplasms express surface molecules typical of chronically virus-stimulated T cells, often termed "exhausted" T cells. We compared the transcriptome of "exhausted" CD8 T cells infiltrating autochthonous melanomas to those of naïve and acutely stimulated CD8 T cells. Despite strong similarities between transcriptional signatures of tumor- and virus-induced exhausted CD8 T cells, notable differences appeared. Among transcriptional regulators, Nr4a2 and Maf were highly overexpr ...[more]