Ontology highlight
ABSTRACT:
SUBMITTER: Hartley JM
PROVIDER: S-EPMC4551445 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Hartley Jonathan M JM Chu Te-Wei TW Peterson Eric M EM Zhang Rui R Yang Jiyuan J Harris Joel J Kopeček Jindřich J
Chembiochem : a European journal of chemical biology 20150702 12
Super-resolution imaging was used to quantify organizational changes in the plasma membrane after treatment with hybrid nanoconjugates. The nanoconjugates crosslinked CD20 on the surface of malignant B cells, thereby inducing apoptosis. Super-resolution images were analyzed by using pair-correlation analysis to determine cluster size and to count the average number of molecules in the clusters. The role of lipid rafts was investigated by pre-treating cells with a cholesterol chelator and actin d ...[more]