Ontology highlight
ABSTRACT:
SUBMITTER: Zirbel CL
PROVIDER: S-EPMC4551918 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Zirbel Craig L CL Roll James J Sweeney Blake A BA Petrov Anton I AI Pirrung Meg M Leontis Neocles B NB
Nucleic acids research 20150629 15
Predicting RNA 3D structure from sequence is a major challenge in biophysics. An important sub-goal is accurately identifying recurrent 3D motifs from RNA internal and hairpin loop sequences extracted from secondary structure (2D) diagrams. We have developed and validated new probabilistic models for 3D motif sequences based on hybrid Stochastic Context-Free Grammars and Markov Random Fields (SCFG/MRF). The SCFG/MRF models are constructed using atomic-resolution RNA 3D structures. To parameteriz ...[more]