Ontology highlight
ABSTRACT:
SUBMITTER: Kann M
PROVIDER: S-EPMC4552122 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Kann Martin M Ettou Sandrine S Jung Youngsook L YL Lenz Maximilian O MO Taglienti Mary E ME Park Peter J PJ Schermer Bernhard B Benzing Thomas T Kreidberg Jordan A JA
Journal of the American Society of Nephrology : JASN 20150130 9
The transcription factor Wilms' tumor suppressor 1 (WT1) is key to podocyte development and viability; however, WT1 transcriptional networks in podocytes remain elusive. We provide a comprehensive analysis of the genome-wide WT1 transcriptional network in podocytes in vivo using chromatin immunoprecipitation followed by sequencing (ChIPseq) and RNA sequencing techniques. Our data show a specific role for WT1 in regulating the podocyte-specific transcriptome through binding to both promoters and ...[more]