Ontology highlight
ABSTRACT:
SUBMITTER: Inacio P
PROVIDER: S-EPMC4552488 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Inácio Patricia P Zuzarte-Luís Vanessa V Ruivo Margarida T G MT Falkard Brie B Nagaraj Nagarjuna N Rooijers Koos K Mann Matthias M Mair Gunnar G Fidock David A DA Mota Maria M MM
EMBO reports 20150625 8
Upon infection of a mammalian host, Plasmodium parasites first replicate inside hepatocytes, generating thousands of new parasites. Although Plasmodium intra-hepatic development represents a substantial metabolic challenge to the host hepatocyte, how infected cells respond to and integrate this stress remains poorly understood. Here, we present proteomic and transcriptomic analyses, revealing that the endoplasmic reticulum (ER)-resident unfolded protein response (UPR) is activated in host hepato ...[more]